case control study of the factor v leiden and factor ii g20210a mutation frequency in women with recurrent pregnancy loss

background: recurrent pregnancy loss (rpl) caused by various genetic and non-genetic factors. after chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause rpl. factor v leiden and factor ii g20210a mutation were the most common mutations cause thrombophilia in the world. objective: the purpose of this study was to determine the frequency of factor v leiden and prothrombine gene mutations in women with rpl compared with women who had uneventful pregnancies. materials and methods: this case control study evaluates the frequency of factor v-leiden and factor ii g20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. the mutations were assessed by pcr-rflp. results: frequency of the factor v leiden among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant. no factor ii g20210 mutation was found among cases and controls. conclusion: these data did not confirm that factor v leiden and factor ii g20210 mutation might play a role in recurrent pregnancy loss in iranian women.